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Embryologically, fusion failure of the olfactory placode, the frontonasal process, and the maxillary process lead to the Tessier No. 3 cleft along the naso-optic groove.
Cage migration also leads to pseudarthrosis formation and fusion failure.
Therefore, SCF has the potential to achieve effective decompression with a lower risk of fusion failure.
An undersized cage cannot maintain interbody fusion, leading to pseudarthrosis formation and fusion failure [ 16, 17].
However, fusion failure still occurs in some patients who undergo TLIF and is mainly derived from intervertebral space collapse or cage migration.
All explants fused appropriately (Fig 2H; n = 9), suggesting that the cleft palate in mutant mice is unlikely to be caused by a fusion failure.
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Fusion-cell-specific Sdc knockdown was sufficient to induce dorsal branch fusion failures, and was also rescued with sdcRESC (Fig 3B).
Dorsal branch fusion failures were observed only rarely in wild-type (0.5 non-fused segments per animal) or sdc heterozygotes (0.8 per animal; Fig 2A).
The skeleton of tetraodontiforms is notable for a reduced number of bones, a number of the separate bony elements of the generalized perciforms having been lost through the processes of reduction, consolidation, fusion, or failure to develop.
A fusion component failure rate database (FCFR-DB) has been set up.
Even if they are satisfied, the filter system is still poor in robustness, i.e., it will crash in the event of fusion center failure.
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