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Furthermore, unfolding of α3 is accounted for in our MD simulations and ensemble analysis of the SAXS data.
Furthermore, unfolding transitions associated with increases in beta-sheet and disordered segment content are associated with an increased tendency to aggregate, suggesting that middle-aged and aged CKm may be more prone to aggregation than young CKm [ 29, 30].
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Furthermore, the unfolding of activation loop (red) and switching of the electrostatic network involving Lys295, Glu310 and Arg409 are the hallmark of the src kinase activation mechanism; the model identifies these metrics without any a priori structural information about the active state of kinase.
Furthermore, although there are no unfolding kinetics data for Ec-RNase HII, it is possible that Ec-RNase HII may not exhibit slow unfolding because Ec-RNase HII is less stable than Ec-RNase HI [ 56].
Furthermore, these simulations suggest that complete unfolding may take only one or a few ns see Figs. 4A and 6A in Raffaini and Ganazzoli (2010).
Furthermore, stability as measured by thermal unfolding in the CD spectrophotometer seems unaffected by the deletion of terminal residues.
Furthermore, the stoichiometry and reversibility of the MTIP unfolding transition are unknown, as is the character of the unfolded state of the protein.
Furthermore, urea denaturation studies indicate highly cooperative unfolding of the ribozyme that is governed by thermodynamic parameters similar to those for forward folding.
Furthermore, the trajectories of technological evolution currently unfolding would not carry as many high-return investment opportunities as past periods of innovation.
Furthermore, we present detailed mechanisms for the unfolding of the Aβ central helix and for the stabilization by the replacement of the three nonpolar residues.
Furthermore, it has been suggested that some unfolding event may be responsible for the thermosensitivity of TRP channels.
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