Furthermore, pauses (well shut-in) in the experiments cause slight permeability drops.
Positive transcription elongation factor b (P-TEFb) then phosphorylates the C-terminal domain (CTD) of Pol II at Ser2, thus reactivating the paused complex9,10,11,12,13. Furthermore, P-TEFb phosphorylates the C-terminal repetitive sequence (CTR) of DSIF, which is analogous to the Pol II CTD, and this modification converts DSIF from a transcriptional repressor to an activator14,15.
Furthermore, the pause time may affect Pp independently of volume [ 32], making the interpretation of Pp-expiratory flow relationship rather complex.
Furthermore, the pausing angles were consistent with those in the absence of ADP, and the angular shift was only 1.1±7.8° (Fig 4G).
Furthermore, only pre-MBT genes that are paused at some point (pre-MBT dual, pre-MBT paused) show enrichment for GAGA, Inr and PB.
Furthermore, we estimated that site closures or paused recruitment due to parental leave of a critical staff member lost 19 years of recruitment.
Furthermore, we found an association between women with paused SSRI exposure during pregnancy and congenital malformations of the heart.
Furthermore, two genome-wide screens for promoter proximal paused RNAP II in Drosophila revealed that approximately 20% of genes in S2 culture cells, and 10% in early embryos, had initiated transcription but were transcriptionally paused 14, 16.
Furthermore, we find that the average half-life of paused Pol II is 7 min, indicating that Pol II pausing is remarkably stable, and not the consequence of fast, repeated rounds of initiation and termination.
Furthermore, a significant percentage of MYC-MAX is located slightly upstream of nearly all the promoter-proximally paused Pol II.
Furthermore, to our knowledge, this is the first study to address a possible confounding by indication by assessing risks associated with paused exposure to SSRIs during pregnancy.
