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Furthermore, it is extremely difficult to predict the disease outcome of cancer patients.
Furthermore, it is extremely difficult to predict the effect of DNA level changes (e.g. mutations, copy number changes, methylation levels) to the phenotype, and therefore we analysed data in the context that is as close to the phenotype as possible, the pathways.
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Furthermore, it is extremely hard to find this vaccine.
Furthermore, as was mentioned in our manuscript, it is extremely difficult to cover the total protein with MS as some areas do not produce suitable tryptic peptides.
It is extremely difficult to manufacture.
It is extremely difficult to tell.
Now it is extremely difficult.
It is extremely difficult to uproot.
It is extremely difficult though, and extremely frustrating.
"It is extremely difficult," she sighs wearily.
It is "extremely difficult to make it profitable," he said.
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