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Furthermore, deprivation of tryptophan by IDO halts the proliferation of T cells at mid-G1 phase, which in concert with the pro-apoptotic activity of kynurenine, leads to diminishing T cell-mediated immune responses and the subsequent development of immune tolerance [ 13- 17].
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Furthermore, sleep deprivation can interfere with analgesic treatments involving opioidergic and serotoninergic mechanisms of action.
Furthermore, socioeconomic deprivation tended to be associated with lower HL, except for the critical dimension as previously reported [4, 22].
Furthermore, food deprivation is accompanied with decreased phosphorylation of intermediate proteins of the PI3K/Akt/mTOR pathway although mTOR phosphorylation does not change during myotubes atrophy [32].
Furthermore, visual deprivation for five days also leads to dramatic changes in the overall excitability of occipital cortex (quantified by phosphene thresholds using TMS [45]).
Furthermore, oestrogen deprivation by ovarian ablation (similar to oestrogen antagonism with tamoxifen) is already established as an effective adjuvant treatment in premenopausal women with modality breast cancer.
Furthermore, although neighbourhood deprivation and urbanicity are correlated, additional association of deprivation with escalation of analgesics exists over and above urbanisation, indicating that other parameters than population density are involved too.
Furthermore, chronic sleep deprivation may contribute to anergy that impairs attendance and work performance.
Furthermore, full visual deprivation causes visual areas to reorganize to process other inputs and sensory modalities (Merabet and Pascual-Leone, 2010; Voss and Zatorre, 2012).
Furthermore none took deprivation, which has recently been shown to be an important prognostic factor (Kogevinas and Porta, 1997; Coleman et al, 1999) into account.
Furthermore, the positive deprivation gap in 10-year survival for women diagnosed during the late 1980s (+4.6%, higher survival in the most deprived) was statistically significant at the 1% level.
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