Furthermore, the deleterious effects of the H3-K56A mutation on DNA damage sensitivity were exacerbated by the H3-S57ph mimic (S57E) and strongly suppressed by the S57A substitution, similar to the interplay with the H3-K56R mutation (Figure 3A).
Furthermore, highly deleterious, yet recessive, mutations may persist in heterozygosity until a compensatory partner arises or becomes linked by recombination.
Furthermore, the deleterious hybrid-forming activity of Rad51p is suppressed in wild-type cells by Srs2p, a Rad51p inhibitor.
Furthermore, no deleterious mutations have been detected in any of the PGE2 synthases, neither in the receptors PTGER2 and TBXA2R (Additional file 1: Figure S3A).
20 Furthermore, the deleterious nature of nearly all known missense mutations can be established via their occurrence in amino acids present in a transmembrane domain and/or conservation among orthologs.
Furthermore, rare, deleterious SNPs have gained interest as the result of their potential role in explaining quantitative trait variation (Gibson 2012), especially in populations that have experienced recent growth (Lohmueller 2013).
Furthermore, the deleterious effects of sepsis are not limited to the period of acute care hospitalization, with a heightened risk of death remaining for years after discharge [ 10, 14].
The prognostic significance of PR expression is present within all breast cancer subsets and, furthermore, the deleterious influence of the absence of PR expression (in ER-positive disease) is still evident despite endocrine therapy (Viale et al, 2007; Dowsett et al, 2008).
Furthermore, many deleterious variants may be detected that are clearly disruptive to a gene or its resultant protein (nonsense, frameshift, canonical +/−1,2 splice site, exon-level deletion); however, this is insufficient evidence for a causative role in any given disease presentation.
Furthermore, since the early life deleterious epigenetic programming can be reversed, at least partly, by favorable psycho-social conditions later in life [ 61], use of self-soothing techniques, such as meditation, may be another promising therapeutic approach.
