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Furthermore, at this locus the allele size distribution is relatively wide in M and S populations, as well as in A. arabiensis, but tightly clustered in A. merus and A. melas.
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Furthermore, the favorable allele at this locus is less frequent in African-Americans, partially explaining the poor response to treatment in the AA population [27], [30].
Bioinformatic prediction tools provide substantial evidence to functional consequences and the fact that we have not found a second heterozygous or homozygous c.899G > C carrier in a set of 1046 healthy subjects and the high conservation at this locus furthermore support a potential association with the phenotype.
Furthermore, association of this locus with RA remains suggestive rather than confirmed at genome-wide significance thresholds and hence this result may represent a false positive finding.
Furthermore, no prior evidence of sex-effects at this locus has been reported.
4 Furthermore, this locus has been shown to be associated with coeliac disease.
Furthermore, a locus by locus AMOVA identified some loci with significant FST across different host-plant groups, suggesting that host-plant linked selection might occur in this species.
The copy number at this locus showed relatively low diversity [ 7], furthermore its diversity was lower among Beijing-genotype strains than among non-Beijing-genotype strains [ 8].
Furthermore, 77% of populations showed significant deviation from Hardy Weinberg equilibrium at this locus, and Microchecker indicated that it was probably due to the presence of a null allele.
Furthermore, the disparity between dsub14 and all other microsatellite loci may be due to non-neutrality at this locus, an assumption of all models estimating Ne.
Furthermore, a recent ancestry-shift refinement effort at the ESR1 locus for breast cancer demonstrated that despite apparent lack of association at this locus in Europeans of a variant that was identified in East-Asians an underlying risk variant common to both Europeans and East-Asians could be identified [3].
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