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Furthermore, alternatively spliced variants of survivin have been reported to interact with BCL2 and inhibit caspase 3 and BCL2-associated X protein (BAX) activity [ 218].
Furthermore, alternatively spliced isoforms that are not membrane anchored may instead be potentially secreted and also be found in the blood.
Furthermore, alternatively spliced transcripts may be extremely useful as cancer markers, since it appears likely that there may be striking contrasts in usage of alternatively spliced transcript variants between normal and tumor tissue than in alterations in the general levels of gene expression.
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Furthermore, alternatively-spliced transcript variants of MUC2 that include variations in intron 30 and exon 30 have been described previously [32].
Furthermore, alternative splicing may regulate the activity of some Mediator subunits: Med12 and Med19 are alternatively spliced in human endothelial cells (Rienzo et al. 2012).
Furthermore, four alternatively spliced forms add another level of complexity.
Furthermore, in alternatively spliced genes, the prevalent splice form has a stronger splice site signal than the non-prevalent form.
Furthermore, an alternatively spliced isoform of TF (asTF) also affects tumor growth independently of VIIa and PARs cleavage, through the activation of integrins α6β1 and αVβ3 on ECs to promote angiogenesis [ 97, 104].
Furthermore, this scheme alternatively formulates the forward problem (which is defined by a closed-form solution) in terms of the depth to the top of the sheet rather than in terms of the depth to its center.
Furthermore, corto acts alternatively as an enhancer of trithorax and an enhancer of polycomb.
Furthermore, some of the alternatively spliced AID variants exhibit disturbed nuclear export and are thus restricted to the nucleus (AID-ivs3) or show a diffuse subcellular localization (AID-ΔE4) (10 and Supporting Information Fig. 4).
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