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This definitive trial gave strong indications for stopping any further trial using non-specific inhibitors of nitric oxide synthase in cardiogenic shock and possibly also in any other cardiovascular area.
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Four of the eight short-term trials measured general QoL, using SF-36, and a further trial used Cantril's ladder (authors own measure using a visual analog scale) 30, 33– 39, 39.
Further trials using statins in asthmatic smokers are indicated.
Further trials using 60 mg daily, with clinical end points, are needed.
Further trials using combinations of therapies in this class or kinase inhibitors with broader target specificities are required.
Trials of single-agent topotecan in patients with metastatic BC demonstrated very modest clinical activity, and further trials using this agent were not recommended [ 31].
Such a varied evidence base concerning a safe, inexpensive and readily implemented treatment makes it important to conduct further trials using optimal research methods [ 18].
Once this cohort is set up, we will apply for funding to undertake further trials using the participants in this study.
However, these findings must be interpreted with caution, and further trials using health-related quality of life as the primary end point are required to confirm this observation.
It would certainly be unethical to conduct any further trials using CP 750,75) as there is clear evidence that it is substantially less effective than paclitaxel/cisplatin.
As this was a retrospective study we would strongly propose a clinical trial to address this specific issue and that further trials using novel strategies should be considered in the HPV−ve/p16−ve group.
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