In addition, KIF5A was further verified to interact with GABAAR-interacting factor 1 (GRIF1), a novel GABAARs interacting protein [ 33], in vivo in brain tissues [ 37], which could be another possible regulatory machinery in GABAA receptors trafficking.
Plectin for its part is further able to interact with actin [62] which in spermatids is enriched within the acroplaxome and at specialized membranous junctions of spermatids and Sertoli cells at the anterior sperm surface [35], [63], [64].
P-ΔNp63α protein was further shown to interact with the Rpn13 protein leading to a proteasome-dependent degradation of p-ΔNp63α and thereby protecting LKB1 from the degradation.
RYBP was first identified in a yeast two-hybrid screen for RING1A and was further shown to interact with the transcription factor YY1 (García et al., 1999).
CypA was further confirmed to interact with VP4 of IBDV using co-immunoprecipitation (CO-IP), GST pull-down, and confocal microscopy assays.
The A. actinomycetemcomitans LtxA was further reported to interact with Cu, Zn superoxide dismutase, which may protect both the bacteria and the LtxA from reactive oxygen species produced by host inflammatory cells (Balashova et al., 2007).
Tachyplesin conjugated to an integrin homing domain (Park et al., 1992; Chen et al., 2001) was further shown to interact with the mitochondrial membranes of cancer cells and to up-regulate members of the death receptor pathway, which suggests that this peptide-conjugate also has more than one effect on cancer cells.
Due to structural mimicry SifA has further been proposed to interact with G-proteins.
Recently, Motin proteins have further been shown to interact with YAP and TAZ via their PPxY motifs and the WW motifs of YAP and TAZ (Chan et al., 2011; Wang et al., 2011; Zhao et al., 2011; Hirate et al., 2013; Hong, 2013; Lucci et al., 2013; Yi et al., 2013).
Next steps are the implementation for support of further command line clients to interact with object-based storage services like Rackspace Cloud Files [43] in order to allow a more detailed investigation of the way, the different clients influence the performance.
