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The first course of seven was involuntary, when I was 18, and the further three courses were voluntary over the next few years.
Response was assessed after three courses, patients with PD or SD went off-study, and responders went on to receive a further three courses of induction therapy.
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A further eleven courses were run during the war years, graduating 152 pilots to a basic flying standard.
Those in CR or with good partial response (PR) (>75% tumour reduction on CT) received a further two courses of treatment.
Two patients who achieved PR after seven courses of treatment underwent lung and liver metastasectomy, respectively; the patients with hepatic resection received radical surgery and received further four courses of the treatment.
Most students then return to university to take a further two year course (a BArch, diploma or MArch).
A further three students restarted the course in the following academic year after voluntary suspension, two for personal or family health problems and one who felt too young to be on the course.
Non-progressing patients were randomised between three further courses of GIP or three courses of paclitaxel.
In the arm A patient, grade 3 diarrhoea appeared after the completion of three courses and further administration of S-1 was stopped.
England's Jodi Ewart Shadoff is a further three shots back and on course for her best LPGA Tour performance.
At evaluation, non-progressing patients (stable disease or objective responses) were randomised between three further similar courses of GIP or three courses of paclitaxel (225 mg m−2 over 3 h after appropriate antihypersensitivity premedication), every 3 weeks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com