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Experiments demonstrating a correlation between toxin persistence in the cytosol and the extent of intoxication further support this possibility: the diminished potency of CT and recombinant CT constructs which are rapidly degraded in the cytosol indicates the cytosolic pool of toxin must be maintained at a certain level for optimal intoxication [6], [37], [44].
Prior studies documenting substantial increases in trial activity in many of these non-high-income regions up through 2005 would further support this possibility [ 4, 5].
To further support this possibility, Furin is frequently expressed in human cancers and its expression correlates with aggressiveness and metastasis, thus making it a potential target for anti-cancer therapies (Christensen et al, 2005).
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The association between TARS autoantibodies and a TNF-α-related autoimmune disorder further supported this possibility.
Further supporting this possibility is the observation that hypertonic aerosols such as saline or mannitol have tussive effects in humans.
Further supporting this possibility, cell death induced by IZ was not accompanied by the activation of caspases, as occurs during apoptosis.
Further supporting this possibility was the observation that the majority of the novel transcripts were detected at very low levels [ 5].
An increase in peripheral T lymphocytes observed in rats 18 h after a single oral dose of Wy-13,876 further supports this possibility.
In addition, there is mounting evidence that compartmentalization occurs in individuals infected with HCV [ 27- 33] and the analysis of E1-E2 cloned sequences in patients related to this outbreak further supports this possibility.
The development of motor phenotypes in zebrafish, following transient expression of either mutant SOD1 or mutant TDP-43, further supports this possibility (Lemmens et al., 2007; Kabashi et al., 2008; Kabashi et al., 2010).
Further supporting this possibility is that the blockade of endogenous IL-21 activity by an IL-21R-Fc fusion protein in the cultured RA synovial membrane cells significantly inhibited the production of inflammatory cytokines [ 28].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com