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These conclusions from small-animal models were further substantiated in exploratory proof-of-concept studies in dogs [17] and pigs [22] with protective positive PEEP ventilation.
The critical role of one or both of these migrant RDC subsets in T cell activation was further substantiated in studies employing dye-labeled CCR7+/+ CL-4 T cells transferred into CCR7−/− recipients.
The 'inside-out' signaling was further substantiated in studies where over-expression of LPP-1 wild type attenuated S1PL siRNA- or 4-DP-mediated increase in electrical resistance (data not shown).
This was further substantiated in a recent paper, where the authors provided evidence that rhl system is able to overcome the absence of the las system by activating specific LasR-controlled functions, including production of 3-oxo-C(12 -HSL and PQS [12 -HSL
Therefore, the results were further substantiated in a model of thioglycollate-induced peritonitis, where the CCL2 levels as well as the cell migration could be readily analyzed.
This structure has been hypothesized to be the ATPase FliI, as further substantiated in studies of a Δ fliI mutant constructed in C. jejuni.
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The presence of functional KATP channels in adult IPCs is further substantiated by in situ hybridization detecting the transcript for the sulfonylurea receptor (Sur) subunit of the KATP channel in those cells.
In the present work, our previous observations on tumor hypoxia are further substantiated by in vivo F-FMISO PET imaging showing a gradual increase in hypoxia following treatment (Fig. 2c).
The presence of endogenous myosin Va at the NMJ was further substantiated by in situ immunofluorescence labelling of the motor protein, since this showed up in numerous punctate structures and aggregates in the close vicinity of the AChR labelling.
It was further substantiated as in the 1H1H COSY spectrum H-7 showed correlation only with H-8 and in HMBC it showed correlation with C-7-OMe at δ 61.9.
Initial characterization of GenK, an enzyme involved in gentamicin biosynthesis, as a Cbl-dependent radical SAM MTase from gene knockout studies was further substantiated through in vitro activity assays with purified and reconstituted GenK from Micromonospora echinospora.
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