However, the genetic interactions between these kinases and phosphatases in A. nidulans require further study prior to the reconstruction of relevant signalling cascades.
However, the relevance for quality of life, need for nutrition and hydration, and ethical consideration are complex and controversial issues that warrant further study prior to achieving consensus and formalizing clinical care guidelines.
Four publications to date have shown promising effects of these Smac peptides in vitro and in vivo; however, further studies are required prior to clinical testing [ 19- 22].
At last, we point out the following research directions in the area of particle filter which are worthy of further studies: How to incorporate prior knowledge into the design of particle filter: the efficiency of particle filter is highly dependent on the number of particles employed to represent the posterior PDF that is of interest.
However, the efficacy and safety of HSC-based immunization strategies need to be further evaluated in detailed studies prior to their implementation to clinical practice.
There is therefore a need for further studies, with information about prior and current cognitive ability and brain size, to investigate the relationship between cognitive ability and brain volume in both men and women over age 75.
The exact contribution of each family member to tumour suppression, in each cell type and tissue, is yet to be fully elucidated and the prognostic and diagnostic utility of these genes, compared to other available biomarkers, will require further large systematic clinical studies prior to clinical laboratory tests for these genes becoming commonplace.
Finally, the burn model we have used has several limitations [ 26] and needs to be optimized prior to further studies.
Although results did not conflict with the prior study, further studies are required to confirm the clinical utility of this measure.
Subsequent studies also demonstrated that HAI antibody was a major determinant of protection, and in further studies, HAI titers of 40 60 prior to infection were clearly associated with protection from infection.
However, these proteins were identified from the non-infective stage, and their presence in the infective stage of the parasite needs to be confirmed prior to further studies on their use in vaccines.
