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Notably, the presence of HLA-B*35 correlated with increased levels of alarmins, including HSPs and HMGB1, in healthy individuals, indicating that the presence of HLA-B*35 induces a stress response and is likely to sensitize endothelial and immune cells to further stressful conditions.
Being able to take a more strategic, precise approach to removing tumours could reduce the need for patients to undergo further stressful procedures.
Regarding the time of experience, traumatic experiences in childhood during sensitive developmental periods were considered influential as they affect the development of neuroendocrine and brain structures and may thereby foster vulnerability to further stressful experiences (e.g., [ 20– 20]).
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This risk may be further compounded by stressful life events and by social isolation.
Treatment side effects and problems have potential to undermine adherence [28, 30], which may negatively impact disease management and outcomes [31]; treatment may be stressful, further reducing HRQOL.
The knowledge of the combined effects of prenatal situation and postnatal interventions can help to further optimize potentially stressful therapeutic interventions and support lung recovery of preterm infants based on biology and increasing clinical evidence.
Autophagy inhibition caused by obatoclax is further augmented in stressful conditions such as starvation.
We show that the wide variability of natural S. cerevisiae strains can be further potentiated under stressful environmental conditions.
Further, it was stressful and difficult to disclose one's mental health status and there was fear that the family or friend may lack the requisite patience.
18 National data further indicates that stressful neighbourhoods, social isolation and community violence are associated with both depression and anxiety disorders.
Further adjustment for stressful life events (model III) did not substantially change the estimate, however the CI widened and the association was no longer statistically significant.
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