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In order to protect the cytoplasm from Na+ toxicity, the accumulated Na+ is then further sequestered into the large vacuoles of the cortical cells.
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The function of normal Htt can further be challenged if sequestered by the mutant protein.
Proteins with no more than two transmembrane domains were sequestered for further analysis.
The outcome of their opposing activities further regulates whether N is sequestered into the multivesicular body or is retained at the endosome limiting membrane and, hence, its availability for activation.
In addition, detailed analysis further identified Arnt2 as another protein sequestered by mutant Nhtt in the model mouse brain.
These are that (a) no further ACP can form, (b) the sequestered ACP does not mature into a more crystalline phase and (c) the solution is not in contact with a crystalline calcium phosphate.
We further hypothesized that soluble VEGF could be sequestered in serum-containing cell culture media, resulting in decreased VEGF-dependent proliferation of human umbilical vein endothelial cells.
The miRNAs predicted to be sequestered by certain transcripts were further included for degradome sequencing data-based identification of the downstream targets.
Since long term Denosumab therapy is generally well tolerated, introduction of Denosumab as a second agent for the inhibition of osteoclast activity, may further deprive tumor cells of growth factors sequestered in the bone matrix.
CryoET tomography tilt slices and segmentation of the 3D reconstructions of various well-defined AH vaults further confirmed that this novel additional mass sequestered within the lumen retains a dynamic morphology.
During autophagy, unwanted proteins and organelles are sorted to double-membraned autophagosomes (Fig. 6F), which are further delivered and fused with lysosomes to degrade sequestered cargos and eventually recycle the generated macromolecules as catabolic substrates.
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