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Further sampling will be required in combination with molecular analysis to determine whether these two groups share an identical echolocation call or whether an additional acoustic pattern exists in this region.
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However, we emphasize that further samples will be required to validate this hypothesis (as this effect was lost when the analysis was limited to males).
Some of these conflicts might still represent actual HGT events, but further taxon sampling will be required to resolve the issue completely.
Further work on more genetic markers (for example, NRY, genome-wide single nucleotide polymorphisms, and even ancient DNA) with extensive sampling will be required to further confirm our speculation regarding the prehistoric peopling scenario(s) in East Asia.
A more systematic and definitive approach to sampling will be required to further assess this finding.
More intensive sampling will be required to unravel this further.
Further studies with prospective samples will be required to evaluate whether amplification of 11q13 is a useful marker for metastatic outcome.
Further research involving a larger sample will be required to validate these findings.
Further genotyping and many more samples will be required, and indeed the discovery of many more risk loci associated with CRC before the question of the potential utility of germline genomic profiling can be definitively answered.
However, rare complications may not be detected in a sample size such as this one, so larger samples will be required to further investigate the safety of this approach to patients with LSS.
From the limited number of samples of RNA available from EBM (n = 11), no correlation was found between the highly variable methylated region at p2 in ESR1 and ESR1 expression, however, further studies in a larger number of samples will be required to investigate such associations.
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