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Results were further replicated in an independent cohort (n = 83).
The results in the controls were further replicated in 10.8% of an independent series of 102 non-cancer controls.
The combined effects of risk genotypes of these eight SNPs in Japanese patients were further replicated in 356 North-American gastric cancer patients.
This was further replicated in 1,803 patients and 1,473 controls in stage 2. We found two loci not previously associated with diabetes susceptibility in and around the genes protein tyrosine phosphatase receptor type D (PTPRD) (P = 8.54x10 -10); odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.36-1.82), and serine racemase (SRR) (P = 3.06x10 -9); OR = 1.28; 95% CI = 1.18-1.39).
This association was further replicated in a Binary Logistic Regression analysis.
The results were further replicated in two different COPD cohorts.
Similar(39)
Approximately one-third (29/85) of the most significant non-MHC SNPs in Stage 1 (Table 1) had original GWAS P-values <0.10 in both the TDT and CMH tests, with only two of these SNPs further replicating in Stage 2 (rs11583328 and rs10469900) (Table 2).
Some parts of A, U, and E blocks were revealed to have been further replicated, resulting in four, four, and six copies, respectively.
We further replicated our results in participants from the National Health and Nutrition Examination Survey (NHANES) 2003 2004.
In the present study, we examined the association for SLE in the 22q11.21 region and further replicated the association of SNP rs2298428 in a total of 4,271 cases and 5,721 controls of Asian ancestry.
We further replicated the association for SF in individuals with type 1 and 2 diabetes.
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