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Cities represent fundamental hubs in the world's energy-flow network, and their role is expected to gain further relevance in the next decades, following the ongoing urbanization process.
The reason for this is twofold: Brain imaging is an important clinical application of PET, with a strong focus on quantitation and likely to gain further relevance in the near future for the detection of early-onset dementia.
Additionally, the examination of sAPPα as downregulated protein may be of further relevance in the differential diagnosis of meningitis, maybe reflecting pre-synaptical pathological [40] or protective processes [18] as seen in neurodegenerative diseases like AD [41], [42].
These considerations gain further relevance in the light of recent insights into the Ras-dependent activation mechanism of Raf.
Data presented here acquire perhaps further relevance in light of a recent paper showing that the expression of IL-10 and IL-10R, despite the great variability, is lower in melanomas compared to normal skin [ 14].
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Of further relevance, all patients in the present study received intravenous chemotherapy through a central venous catheter rather than through a peripheral vein, and so the temperature of the testing arm was not affected by infusion-related issues.
Of further relevance, open label and pilot studies in patients with spinal muscular atrophy have suggested potential benefit with valproic acid (Weihl et al., 2006; Swoboda et al., 2009).
"Magna Carta takes on further relevance today.
The findings of this study have further clinical relevance in a second, perhaps less expected, respect.
In addition to SV40 ST, other viral-transforming proteins also interact with PP2A, further accentuating its relevance in cellular transformation.
The relatively high prevalence of this variant among unaffected Europeans [ 30] further undermines its relevance in a clinical context.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com