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As such, it is an improvement on current methods and lays the basis for further refinements using more extensive datasets, such as community based diagnoses.
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Such values may require further refinement using trial-and-error procedures upon implementation.
After several rounds, 200 structures were calculated and 100 structures with lowest target function were selected for further refinement using the AMBER program (version 7.0) [59].
Using a whole-genome scan employing 287 single-nucleotide polymorphic (SNP) markers and further refinement using six additional SNP markers and four microsatellite markers, the causative mutation was mapped to a 5.3-cM region on chromosome 4.
However, these values need further refinement using additional samplings.
Further refinement using the exclusion and inclusion criteria and duplicate exclusion resulted in 47 studies identified and reviewed (table 1).
These full atomic structures can be used as starting points for further refinement using physics-based approaches, or more detailed knowledge-based approaches.
First, the items and domains of MORE will undergo further refinement using cognitive debriefing interviews with a wide range of international stakeholders.
Further refinement using manual checking by experts of the 180,000 names assigned by the software produced an estimated final sensitivity of 97%.
The model was subjected to further refinement using the md_refine.mcr macro of YASARA and to 1 ns constant temperature (300 K) and pressure (1 bar) molecular dynamics (MD) simulations using the AMBER03 force field.
Based on the calculated scores and further refinement using the augmented degree of novelty compared to existing annotations and a minimum score threshold, novel GO terms are assigned to the genes in the target species.
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