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Hence, no further reduction of data was required through PCA.
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This is not the case as the knockdown of Ascl1b in the ascl1a/ pia null mutant [ 46] did not lead to a further reduction of endocrine cells (data not shown).
However, knockdown of ADAM17 in combination with knockdown of ADAM9 or ADAM12, which have both been implicated in HB-EGF shedding in other cells, caused no further reduction of the PMA response (data not shown), suggesting that the residual HB-EGF shedding is rather due to incomplete knockdown of ADAM17.
An additional benefit is the further reduction of the size of the data set while preserving all of the information contained in the original.
The Fine Feature Selection was able to further reduce the number of features to 361 for the 60-month and 102 for the 36-month data sets (a further reduction of 39.2% and 51.9%).
The statistical power of these analyses is also limited by the small number of HIV-positive children in the study and by further reduction of the sample size due to missing data for age and nutritional status.
Hypertonic induction for up to 3 hrs did not lead to further reduction of histone H3 level in OREBP−/− fibroblasts (data not shown), suggesting that the initiation of histone eviction in response to hypertonic stress was carried out in an OREBP-independent manner, but OREBP might further promote nucleosome eviction upon binding to the ORE.
A further reduction of bias is achieved by gathering not only child self-report data, but also the caregivers' view on children's development.
It may be that the continued efforts of the programs from which these data were drawn have been pivotal in the further reduction of visual impairment.
We should always seek further reduction of such errors.
Cleansing the data "will allow us to reduce re-work and manual intervention on claims, and prepares the ground for further reduction of processing costs in future years," says the document.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com