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A synthetic composite promoter produced evening-time expression, which was further recapitulated by a simple phase-vector model.
The suppression of renal cortical TGF-β, collagen IV and mesangial expansion brought about by ARIs is now further recapitulated with the genetic mouse models deficient in Ar in our current investigation.
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And, the transcript lists of orthologous genes can further recapitulate the transcription changes.
In addition to the intestinal phenotype these pigs further recapitulate the human phenotype by display of a blocked bile duct, liver lesions, blocked pancreatic duct, and a congealed gallbladder [ 15, 62].
Ectopic overexpression of NANOG via lentiviral transduction further recapitulates saRNA results, providing proof-of-concept that RNAa may be utilized to activate development-related genes and manipulate cell fate.
In addition, the finding that the IPA-generated network based on the 331 mortality-predicting transcripts (Additional file 4: Figure S1) included the Cell Death and Survival and Cellular Function and Maintenance functions, further recapitulates the relevance of these processes in old-age mortality.
The approach also captures tissue specificity while further recapitulating results from previous genomic analyses.
Finally, MUC-1 stains of MCF-7 spheroids demonstrated a basement membrane-like structure around the outer edge, further recapitulating ductal anatomy.
In this issue of Breast Cancer Research, Rajkumar and coworkers [ 1] take a step further in recapitulating the protective effect of pregnancy.
Further, these phenotypes are recapitulated in humans bearing heterozygous germline p63 mutations.
In the past years, these mouse models have been further improved to recapitulate the salient features of human BRCA1-associated breast cancer, such as 'triple-negative' status, increased genomic instability and increased expression of basal epithelial markers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com