Molecular modeling studies helped to further rationalise anti-apoptotic Bcl-2 binding, and identified compounds 8a and 8e as candidates for further development as Bcl-2 inhibitory anticancer agents.
> -wrap-foot> This classification helps in the interpretation of study outcomes and can also be used to further rationalise the selection of markers for inclusion in future studies.
This assumption is further rationalised by comparing the p Ka (at standard lab conditions) of acetic acid, 4.76, and the hydronium ion, 0.0 [ 25].
How long before the decision is taken to rationalise further by stopping more lightly used stations from being staffed at all?
However, the need to cut hospital budget and reduce the number of bed requires further efforts to rationalise the use of beds.
Although a role for the class of ligand-independent ALK mutants such as ALKF1174 and ALKR1275 is simple to rationalise, further work will be required to answer the more challenging issue of the significance of the ligand-dependent class of ALK mutants, if any, in neuroblastoma progression.
In this communication we further explore possibilities to rationalise those results.
We made a choice to rationalise these further into common groups.
These results reinforce our contention that these metastable switchable state materials can be understood, rationalised and further developed using core chemical principles.
Ligand-based predictions provide a basis for further analysis when attempting to rationalise mechanism-of-action.
