Sentence examples for further rationale of from inspiring English sources

For a further rationale of the current work the reader is referred to the companion paper [21].

In addition, leukemia-initiating cells (LICs), which are responsible for relapse of leukemia, could be cleared by ATRA/ATO based treatment in murine models, providing further rationale of combined use of the two agents (Au et al., 2001, Ito et al., 2008, Nasr and de The, 2010, Nasr et al., 2008, Zhou et al., 2010).

Additionally, protease dysregulation can also cause COPD in humans (in the case of patients with α-1 anti-trypsin deficiency), thereby providing further rationale for use of elastase to induce features of COPD in mice.

These studies provide further rationale for use of low-dose aspirin for the prevention of preeclampsia, owing to a different mechanism of action: the known ability of aspirin to modulate thromboxane- but not prostacyclin-mediated vasoconstriction (Masotti et al., 1979; Thorp et al., 1988).

In addition, special issues with the taxanes provide further rationale for application of delivery systems.

We estimate that breast tumours are twice as likely to express high levels of P-Akt, providing further rationale for developing inhibitors of this pathway for the treatment of cancer.

In conclusion, our data demonstrate that the presence of chemically senescent prostate cancer cells does not significantly enhance the growth of tumour xenografts, providing further rationale for the development of anticancer strategies that efficiently induce senescence in advanced cancers.

12 Clearly, this reparative potential is not capable of an adequate response to significant myocardial damage but the discovery of this endogenous repair process has provided a further rationale for the use of cell therapy based on the amplification of this natural process.

This highlights the challenges in defining a single optimal cut-point for risk stratification using heterogeneous populations of HRneg/Tneg breast cancer cases, and provides further rationale for the use of conditional risk models such as recursive partitioning (rpart).

The beta-barrel containing the active site is highly conserved between ScCTS1 (PDB 2UY2 [25]) and AfChiA1 (PDB 2XVP [23]) with an RMSD of 1.2 Å for 270 Cα atoms providing further rationale for our choice of surrogate.

Further rationale for combined inhibition of PI3K and ER comes from studies using inhibitors of TORC1 or HER2.