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We further postulated that identical genomic sites in different genes can be selectively modified using this strategy by judiciously selecting proximal dCas9-binding sites to differentiate the identical genomic sites.
The model further postulated that stimuli elevated nuclear Ca2+, activating CAMKIV and MAPK.
They further postulated that originating mutations can occur in NSCs (Fig. 1).
We further postulated that essential factors should be prominent in the local networks of other key regulators as they likely serve as hubs between the connected sub-networks.
Margulis further postulated that eukaryotic cilia were also originally spirochetes and that cytoplasm evolved from a symbiotic relationship between eubacteria and archaebacteria (see archaea).
We further postulated that chronic GVHD, whatever its cause, involves thymic epithelium as a target organ.
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Therefore one may further postulate, that initial chromosomal gains and losses of a cell of cancer lineage should reflect the tissue origin of the CCL.
The association between birth weight and adult weight suggests that there are enduring effects on later obesity risk [ 11], and we further postulate that reduction in birth weight will exert a protective effect on later obesity risk.
We further postulate that apart from calcineurin, other constitutively active phosphatase(s) partake in TFEB dephosphorylation and consequent activation.
We further postulate that this paradigm can mechanistically link abnormalities in the PI3K Akt pathway to the development of autoimmunity.
Computational models further postulate that the activation of a sufficient number of semantic features may lead to activation of the whole semantic representation via a pattern-completion-like process8,9,11.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com