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This study, based on computer simulations, analysed the degree of predictivity of pilot trials on six subjects, with the idea of a further pivotal trial on 18 or more volunteers aimed at assessing bioequivalence.
Rodent and rabbit models are recommended for 'mechanism' or 'proof of principle' studies when data regarding toxicity, formulation, dose response and/or safety are needed before further pivotal studies.
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NRDC's India Initiative is deeply engaged in efforts to accelerate energy efficiency and clean energy development in India, and I would love to speak with you further about the pivotal role that both of these efforts could play in securing India's energy future.
Remote sensing further plays a pivotal role in guiding grazing management by providing information in support of analysis, modeling and forecasting for decision support (Angerer 2008; Kawamura and Akiyama 2010).
In the same experiment, the removal of the receptor antagonist from the brain surface restored CSD-induced dilation, further supporting a pivotal role for CGRP in determining transient arteriolar dilation in the first phases of CSD [188].
Act Three should ideally run another 30 minutes and this is when the action mounts further and the pivotal conclusion occurs.
Other than this recognized role, we further noticed a pivotal role for Jak2 in the regulation of the capacity for DCs to mediate innate immune response.
These data further support a pivotal role for autophagy in C. trachomatis elimination and indicate a role for Irga6 as regulator of IFNγ-induced autophagy.
These phenotypes further demonstrate a pivotal role of the AMPK molecule in the organization of behavioral and physiological responses to nutrient-limitations, and that such responses appear to be highly conserved throughout the Metazoa.
Our results further strengthen the pivotal role of glia cells in glutamatergic transmission in the retina.
We used our model to further demonstrate the pivotal role of COX-2 overexpression in CRC cell survival.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com