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Inability to seek timely medical care might further negatively affect these HBV patients' HRQoL.
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Conscripts' tasks requiring both strength and aerobic capacity, such as loaded marching, may be further negatively affected by obesity [ 24], demonstrating a situation where several components may play an important role in the aetiology of musculoskeletal injury.
Further, downsizing negatively affects firm reputation from an institutional perspective (Flanagan and O'Shaughnessy 2005; Love and Kraatz 2009).
A further aspect that may negatively affect patients' QoL, mainly in the long term, is the presence of late postoperative complications such as hernias, urinary tract infections, stenosis of the urinary stoma, peristomal skin lesions, prolapse of the stoma and the weight gain, able to worsen the ostomy management.
Further, these cognitive difficulties may negatively affect other cognitive functions such as verbal learning.
Further, climate change itself will negatively affect global food yields, costs, and accessibility as farming, fisheries, and agricultural production are affected by long-term shifts in climatic and environmental conditions and increased adverse weather events (McMichael and Lindgren 2011).
Climate change has the potential to increase the already high primary production in upwelling systems, which in turn can further increase oxygen stress and negatively affect food web structure, and fisheries.
Linguistic and cultural differences further hinder credible international communication and negatively affect the confidence of international buyers, leading to high transaction costs for buyers trying to precisely identify high quality exporters (Hallak 2006; Hummels and Klenow 2005).
They were excluded from further data analysis because serious outliers negatively affect and thus bias the model.
Moreover, pooling all published studies evaluating this putative association further suggests that KRAS mutations strongly negatively affect the probability of objective response to cetuximab treatment.
Together, these observations suggest that the increased concentrations of S1P and SDF-1 in the BM negatively affect HSPC egress, further highlighting the fact that both S1P and SDF-1 levels must be tightly regulated for balanced HSPCs mobilization.
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