We also saw that, even when lysines of Ngn3 have been mutated, further mutation of cysteines has little effect on half-life.
Thus, in HNPCC, in which a single further mutation confers a mutator phenotype, there is no increased risk of embryonal cancers, which require fewer oncogenic mutations in their formation, despite an increased colon cancer risk corresponding to the larger number of oncogenic mutations in the pathogenesis of colon cancer.
We do not know yet whether the different cell components of the M38 tumor, present both in primary cultures and in the LM38-LP subline, are the differentiated progeny of a single mutated stem cell or arose only after further mutation(s) of lineage-committed progenitor cells [ 20, 36, 37].
These manoeuvrings suggest a further mutation in the life of the Russian intelligentsia.
Even so, the place is less an escape from Los Angeles than a further mutation of its hyperactive urban genes.
With each passing day, however, more rounds of cell division mean more DNA copying and more chances for further mutation.
The ability to type for these polymorphisms provides an opportunity to assess further mutation in ruminants.
But a new wave of DJs and a further mutation of techno was bubbling beneath the surface that would kick against the big and the beige.
Further mutation analysis at the 9th position of B133a using various amino acids suggests that hydrophobic amino acids are effective for the integrin α2β1-mediated cell attachment activity.
Furthermore, the affinity of obtained monoclonal Abs (mAbs) can be improved through further mutation followed by selection, a process analogous to "affinity maturation" that occurs in vivo.
Further, mutation types consistent with a gene's propensity to lose or gain function in cancer for example, truncation of a tumor suppressor, hotspot mutation in an oncogene or amplification of a known gene target resulted in an elevated review priority.
