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In addition, further methods development, such as a Bayesian treatment of the penetrance matrix, would enable us to analyze categorical traits without specifying the penetrance matrix in advance.
Because CCMpred is free and open-source software, we hope that it also can serve as a basis for further methods development in this field.
Our main contribution is the model-based approach for long-range phasing, which has intuitive parameterization, probabilistic output, and clear structure, which can provide insights to distribution of haplotypes and lends itself to further methods development.
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We resolved some metabolites but no doubt more peaks could be resolved with further method development.
However, further method development especially in the field of structure elucidation of complex secondary metabolites is necessary to exploit the full potential of metabolomics in environmental studies.
Further method development is underway to circumvent this problem.
Thus, further method development was performed with the DCM/methanol mixture.
As mentioned above, further method development will aim to improve the sensitivity and mass accuracy for N-glycan MALDI imaging.
Further method development implementing core shell particle C18 material was carried out in order to allow the ultra-high performance assay on standard HPLC instrumentation.
This suggests ample opportunities for further method development and performance improvement, and our framework provides the necessary foundation upon which this progress can be built.
The second limiting factor deserving consideration is the need for further method development and protocol adjustment, even when similar protocols have already been published.
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