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Although we have not tested whether the RPE cells we obtained are fully functional, e.g. by cell transplantation in animal models, with further methodological optimization, this approach would facilitate the functional RPE cells' generation from human fibroblasts.
Further methodological optimization will likely enable higher resolution analyses.
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Beyond its obvious suitability for molecular taxonomy in its current version, the suggested clustering optimization algorithm is an excellent starting point for further methodological improvements.
Nevertheless, further methodological advances are needed to obtain truly routine and widely available in situ14C analysis.
It is here that the call for further methodological developments clearly emerges.
Further methodological details are available [14 16].
Further methodological details on model development are provided in the following sections.
Needs for further methodological development and practical implementation are drawn as conclusions.
To discard this alternative interpretation further methodological developments have to address this issue in depth.
Further methodological development is required to include these regions within the imaging volume.
Further methodological details for delineation of the Cg1, PL, and IL borders were described in Suppl.
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