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Further, lower doses of ornidazole (5 and 10 mM) had greater inhibitory effect when added at 0 h, while addition of ornidazole at 3.5 h required higher doses of ornidazole (25 mM) to cause significant inhibition of acrosome reaction.
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As it was anticipated that myelotoxicity might be dose limiting even at dose level 1a, further (lower) dose escalation schemes were devised.
Chlordecone produced the strongest response, so the team experimented further with lower doses of this compound.
The patient became unstable when attempts were made to further lower lithium dose, until olanzapine (5 mg/day) was added to the treatment.
Still, in part B, the provisional MTDs for both doublets were found to be excessively toxic, requiring further evaluation of lower doses.
There needs to be greater awareness of the potential complications of Avastin among neonatologists and ophthalmologists until further trials indicate that lower doses or different preparations are not only effective but safe.
This finding further supports the premise that lower doses of toceranib are associated with biologically relevant plasma concentrations of drug.
Further studies would include adding lower doses of these cytokines, and/or combinations of cytokines, for a longer period during myelin formation.
> -wrap-foot> While dosing of unacidified WTRs enhances treatment, prior regeneration of the constituent coagulants with acid improves removals of solids, COD, and phosphorus by a further 20 30% at much lower doses (Table 6).
However, the influence of pharmacokinetic parameters on the rate of false positives should be further explored to evaluate how lower doses can influence the precision of the concentration/QTc effect model to be used in QT assessment studies.
Further studies using lower dose scans with assessment of diagnostic accuracies should be performed to gain maximal benefit of the noise reduction achieved with MBIR.
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