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As it was anticipated that myelotoxicity might be dose limiting even at dose level 1a, further (lower) dose escalation schemes were devised.
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The patient became unstable when attempts were made to further lower lithium dose, until olanzapine (5 mg/day) was added to the treatment.
Chlordecone produced the strongest response, so the team experimented further with lower doses of this compound.
Further studies using lower dose scans with assessment of diagnostic accuracies should be performed to gain maximal benefit of the noise reduction achieved with MBIR.
In five patients (19%), the dose was de-escalated and patients were treated further at a lower dose.
The effects of monoclonal antibodies were further studied at a lower dose.
Therefore, further experiments with a lower dose range of BEZ235 were performed.
One of these patients had repeated fever with the intrapleural injections and thus the dose of intrapleural SRL172 was reduced with no further fever at the lower dose.
A supportive analysis, in the form of an ANCOVA that included a treatment by dose group (i.e. higher or lower dose) interaction, further confirmed non-inferiority of fluticasone/formoterol for this secondary parameter.
Still, in part B, the provisional MTDs for both doublets were found to be excessively toxic, requiring further evaluation of lower doses.
Noteworthy, control sh/scr cells challenged with higher 5-FU dose (10 μM) generated a number of colonies significantly higher with respect to MKK3-depleted cells treated with the lower dose (1.0 μM), further confirming the evidence that combined treatments allow chemotherapeutic dose reduction.
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