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The cardiovascular response of neonatal patients is a largely unexplored area and presents a further level of complexity, not only owing to their small size but also owing to their complex response to hypoxia [ 48].
The service that the company was going to offer in Germany could potentially be paid for, in part, by an insurance policy, adding a further level of complexity.
To add a further level of complexity, micropatterned co-cultures were obtained using bovine serum albumin to promote cell adhesion.
In addition, recent reports show that gene copy number adds a further level of complexity in understanding the molecular context of health and disease states.
A further level of complexity in regard to the role of Bid in the response to genotoxic stress lies in the fact that Bid can be activated through several distinct mechanisms after DNA damage.
A further level of complexity arises in that, beyond their ability to activate and inactivate FRT antimicrobials, these protease families are regulated throughout the menstrual cycle by protease inhibitors present in the genital secretions.
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This adds further levels of complexity and can be time consuming".
In addition, this novel platform allows to add further levels of complexity, such as multiple nuclei, adatom surface diffusion, aggregation, particle detachment, etc.
In the skin, the ability of β-catenin to activate or inhibit other signalling pathways, such as Notch and Hedgehog, provides further levels of complexity in the regulation of stem cell renewal and lineage selection [25].
Furthermore the final outcome to Ras/Erk pathway activation is subject to regulation by intrincate, as yet not fully understood positive and negative feedback loops [ 54- 56] that may add further levels of complexity in settings of incomplete Ras-GTP blockade by MSOR.
Whether the interaction with the full-length protein adds a further level of biological complexity remains to be determined.
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