Further, the Ingenuity Pathway Analysis (Ingenuity® Systems, www.ingenuity.com) database identifies 139 genes as being targets for drugs for psychiatric illness.
Further, the Ingenuity Pathway Analysis (IPA, Ingenuity® Systems, www.ingenuity.com) showed that in several networks our result genes are not the most strategic genes of the network, but rather the targets of other network molecules instead (Additional file 6: Table S5, Table S6).
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Commonly reorganized metastamiRs (upregulated and downregulated) across the manifold of metastatic tumors are further examined Ingenuity Pathway analysis, Target Scan, and miRBase to determine the gene targets.
We further used Ingenuity Pathway Analysis (IPA) software [ 26] to study the related functions of these five genes, and it was found that they are all involved in the behavior function, mostly mouse locomotor activity, with a significance value of 10-21.
The gene signatures were further examined using Ingenuity Pathways Knowledge Base (Ingenuity, Mountain View, USA), one of the largest manual curated database, to identify associations with cellular functions and diseases.
The raw data were normalized, quality controlled, and filtered by Almac Diagnostics to produce gene lists and further analyzed with Ingenuity Pathway Analysis software (Ingenuity Systems, Redwood City, CA, USA).
289 expression profiles with FDR < 5 (less than 5% chance of genes falsely identified as differentially expressed) were selected for further investigation by Ingenuity Pathway Analysis (IPA) software (Ingenuity).
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The results were further analysed with ingenuity pathway analysis.
