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The release of these vaccine strains, some of which (including BTV-2 and 16) have persisted in the field, has further increased the level of genetic diversity within the European BTV population [45] [47].
Interference with ribosomal biogenesis by actinomycin D further increased the level of apoptosis in L11-deficient embryos (data not shown), as ribosomal biogenesis was already compromised in these embryos.
Co-treatment of rats with CQ further increased the level of LC3-II but decreased the degradation of p62.
Treatment of MAS-expressing cells with a specific MAS agonist, AR- agonist, further increased the level of phosphorylation of FLNa 10-fold.
It is interesting to note that the inhibition of PKB signaling by wortmannin further increased the level of neuronal death caused by the absence of ERK5.
On the contrary, 120 min after tunicamycin addition, ISRIB further increased the level of eIF2α phosphorylation, approaching that obtained with thapsigargin.
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HFD further increased the levels of LDL-cholesterol in ApoE−/− mice (p<0.05).
Treatment of astrocytes with a combination of both gp120 and cocaine, however, further increased the levels of activated caspase-3 compared with cells exposed to either agent alone (p<0.05 versus cocaine or gp120).
Furthermore, consistent with our above and the previous [31] observations, the basal levels of ERα protein were about two-fold higher in purified splenic B cells from female mice than the age-matched male mice and IFN-α treatment of B cells further increased the levels of ERα protein ∼2-4-fold (Fig. 2D).
PC + NaHS further increased the levels of phosphorylated PI3K, Akt, GSK-3β (p < 0.05 versus I/R + NaHS group).
CQ further increased the levels of LC3-II with 250 μM FAC, suggesting this dose of FAC mediates autophagic induction (increased autophagic flux).
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