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Combining biomarker miRNA pairs within the same set further improves sensitivity and specificity (Fig. 3 and Table 2).
Finally, we found that incorporation of estrogen-receptor and TNBC status improves the sensitivity of the Manchester Scoring method (42.9% to 64.3%), and furthermore, incorporation of PTEN status further improves sensitivity (42.9% to 85.7%).
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On-chip integration of low-noise preamplifiers may further improve sensitivity performance.
However, further improved sensitivity and accuracy of the devices are required, so that the development of a novel nanostructure design with special optical properties for high sensitivity and selectivity has become a priotiry.
This follow-up work provides an optimized structure design based on the integration of double 60° bend waveguides and modified center-defect photonic crystal microcavity to further improve sensitivity.
Imaging these new probes with our technique will further improve sensitivity of calcium signal measurements.
Since the key width of an index (w) here is less than the read length, we are able to apply the mask at all possible starting positions offset from the beginning of the read to increase the number of lookups performed per read and thus further improve sensitivity.
This stage adds extra cluster pairs to the output, further improving sensitivity.
The inclusion of the IgG test result modestly further improved sensitivity.
We further improved sensitivity by using InParanoid, one of the best programs for ortholog detection [ 33] and applying iterative pairwise comparisons.
It is possible that extending the CILIOGENESIS data set to include factors regulating the ciliary responsiveness to Hedgehog or Wnt activators or suppressors could further improve sensitivity.
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