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We hypothesized that if loss of LERP impairs lysosomal activity, further impairment due to chloroquine exposure would enhance the lysosomal defect and result in enhanced lethality.
Consequent leakage of sugars across the impaired intestinal barrier causes further impairment of this barrier and ultimately death through an unknown proximal event.
Some of our subjects with or without IFG could have impaired glucose tolerance and represent a different category with further impairment in GDI.
Therefore, our conclusion from the discussion presented above is that an impaired incretin effect, most likely due to impaired islet responses to the incretin hormones, is an early sign of impaired glucose metabolism, perhaps associated with insulin resistance, and that a further impairment is seen as glucose intolerance develops.
As shown in Fig. 4, glucose tolerance is impaired in both sexes even at the lowest dose of rapamycin, with further impairment seen in mice exposed to the highest rapamycin dose.
The environmental fund is group of scientists, lawyers and conservationists, incorporated in New York, that seeks to protect the environment from further impairment.
To determine whether low tidal ventilation in patients without lung injury results in an increase in the amount of atelectasis and a further impairment of gas exchange during general anesthesia.
Continued downward drifts of energy industry fundamentals could bring further impairment on book value.
This includes further impairment to goodwill and write-downs of account receivables and inventory.
Acute administration of risperidone at high dose significantly reduced performance (percent correct rejection) in chronically saline-treated rats, but in a similar fashion as in Exp. 1, chronic nicotine lowered accuracy but attenuated further impairment with acute risperidone.
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We now expect flat house prices in 2010 (previously down 5%) and thus do not anticipate any further impairments across the sector (we believe prices need to fall 14% from current levels for further impairments).
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