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The other finding is the fact that the stringency of the REM definition itself not only determines the functional state of those reaching REM, but also – as a consequence – the degree of further functional improvement if REM is sustained.
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Further functional improvements have been reported when cellular or pharmaceutical agents have been incorporated into the delivery system.
On the other hand, further functional improvements of hepatocytes were achieved in HGF- or HGF/heparin-containing gel cultures.
To examine how health-related, socioeconomic, and environmental factors combine to influence the onset of activity of daily living (ADL) limitations or prognosis for death or further functional deterioration or improvement among elderly people.
Nevertheless, the majority of RIS/RIS subjects experienced further symptom and functional improvement with continued treatment.
Moreover, combining tDCS with peripheral stimulation or motor training further enhances the functional improvement (5, 6, 15).
The genes identified provide excellent candidates for further functional characterization and genetic improvement of lignocellulosic biomass properties toward increased saccharification efficiency.
Change in the ARAT score was found to predict 30.8% of the change in MAL amount of use, further supporting the idea that functional improvement is necessary for increased arm use.
To get further insight into the mechanism of functional improvement, we characterized four weeks after transplantation serotonergic fibers (5HT), on a spinal cord segment located 1 mm below the lesion site in injured-only and grafted animals.
The efficacy of GRG shown with histological methods prompts us to continue our investigation, assessing functional improvement in rats and further establishing GRG capabilities in rabbit experimental model.
In addition, compounds 8 and 16 exhibited the desired multi-target profile against A1R, A2AR and PDE10A, which would serve as good starting points for further functional efficacy assessment and analog modification for the improvement of selectivity.
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