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Responding patients or those with stable disease could continue treatment for a further four cycles of intermittent chronomodulated therapy with assessment of tumor response after four and six cycles (day 85 and 127, respectively).
In cases in which disease remained inoperable, a further four cycles of CapOx could be delivered before re-evaluation.
Patients undergoing liver resection after four cycles of CapOx received a further four cycles of post-operative chemotherapy.
The patient received a further four cycles of this treatment, in an outpatient setting, and no longer complained of anginal pain.
She had a partial response after two cycles, which was sustained on CT scan after a further four cycles of treatment.
In another pilot trial, 133 patients with large (> 3 cm) or locally advanced tumours and a clinical response to four cycles of cyclophosphamide, vincristine, doxorubicin and prednisolone (CVAP) were randomly assigned either to continue for a further four cycles with CVAP or to four cycles of docetaxel.
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Just a year after Georgina's birth, Sant got pregnant after a further three cycles of natural-cycle IVF.
Successive cooling and re-heating showed the gradual emergence of two endothermic peaks (ca. 273 and 280 K) in this temperature range, becoming identifiable by the third re-heat and then the peaks gradually sharpened and became better defined on the further two cycles of cooling-heating.
Ktrans reduction was increased following a further six cycles of bevacizumab with conventional chemotherapy.
The patient then received a further five cycles of this treatment without any chest pain.
Those assigned to maintenance received a further six cycles of CVM after induction.
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