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Overexpression of EBP1 sensitised LTLT-Ca cells to tamoxifen and IPA-3 further enhanced sensitivity to tamoxifen.
The implementation of other instrumental modifications such as multi-inlet capillaries and dual-stage ion funnels has led to further enhanced sensitivity [ 60].
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We observed that both FADD and TRADD deficiencies suppressed TNF-induced apoptosis (with or without CHX) in Sharpin knockdown HaCaT cells, which further indicates that enhanced sensitivity of sharpin-deficient keratinocytes to TNF is FADD and TRADD- dependent.
Taking advantage of the unique generous and uniform hot spots on the surface of chemically etched Ag nanowires, we optimized the distribution of hot spots on the present substrate, thereby achieving further enhanced SERS intensity and sensitivity.
Further, treatment with this peptide enhanced sensitivity and overcame resistance to trastuzumab in cells expressing amplified HER-2.
Here, the further molecular reaction sequence is studied with enhanced sensitivity, using MBMS coupled with resonance-enhanced multiphoton ionization (REMPI).
To further address the molecular mechanism involved in the enhanced sensitivity of androgen withdrawal in LNCaP/IL-6 1, the infLNCaP/IL-6 1-6 overexpression on global gene expression was assessed by gene microarray analysis.
The new platform incorporated an improved electrospray ionization source and interface for enhanced sensitivity, and providing the basis for further benefits based upon implementation of multiplexed IMS.
Further, it is also likely that other insulin sensitive tissues (e.g., muscle or fat) could show enhanced sensitivity to PIO's effects on insulin, resulting in more robust changes in insulin receptor signaling.
An improvement in the mapping resolution afforded by an advanced intercross population and enhanced sensitivity of the transcriptome analysis by RNA-Seq provides further incentives for application of this strategy.
The earlier detection of osteoblastic activity by F-fluoride PET than with MDP bone scintigraphy (Even-Sapir et al, 2006) is further enhanced by the increased spatial resolution of PET imaging that increases the sensitivity of the technique.
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