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It is well known that HSF-1 is post-translationally modified by phosphorylation and modification of SUMO-1 to achieve a further dynamic range of action (Hong et al., 2001).
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The signal swing of the analog functional blocks (THA and MDAC sections) is allowed to exceed the supply voltage (1.8 V), which further increases the dynamic range of the circuit.
To further expand the dynamic range, we attempted to exchange the donor and acceptor in the above constructs to place the donor and acceptor molecule at the C- and N-terminus, respectively, of CaM-M13 (Figure 1A).
Increasing the induction time beyond 6 hr can further extend this dynamic range.
In addition, the linear k-space sampling used in this study is preferred to further increase the dynamic range and optimize the sequence for CA transit time.
A smaller time window (89 133 ms), as used in the study of Lascano et al. (2009), would have further reduced the dynamic range.
The goals of this analysis were to further evaluate the dynamic range of these biomarkers upon strong induction with rifampicin and to compare and evaluate whether these biomarkers can serve as covariates to explain intersubject variability of midostaurin pharmacokinetics in a clinical setting.
The VLC system is further limited by the dynamic range of the LED.
This wide dynamic range further attests our unbiased Lc-Ms approach.
Higher thresholds would improve the resolution further but reduce the dynamic range.
However, the expected reduced calcium influx predicts a further reduction in the dynamic range of photoreceptor activity.
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