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ROS are generated by an electron transport through the membrane forming O2−∙ that can further disproportionate forming hydrogen peroxide (H2O2) or, in presence of nitric oxide (∙NO), creating peroxynitrite (ONOO–).
Two effects might occur: first, increased taxane brain concentrations simply as a consequence of the higher plasma levels of the taxanes; and second, a further, disproportionate increase in brain concentration relative to the plasma levels because of inhibition of P-gp at the BBB, and/or possibly saturation of P-gp activity at the BBB because of the much higher plasma taxane levels.
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"I can't imagine there are easy-to-do measures that would enhance safety further without disproportionate cost".
Further, a disproportionate number of patients with diagnosed aspergillosis were treated with voriconazole.
Mr. Obama further noted that disproportionate attention from the police was an unwelcome fact of black life in America.
The film and recording industries have helped further to give disproportionate promience to a few highly successful and undeniably effective examples like those for piano by the Norwegian Edvard Grieg (in A minor) and the Russians Pyotr Ilyich Tchaikovsky (in B flat minor) and Sergey Rachmaninoff (in C minor).
With the prospect of greenhouse gases produced further south causing disproportionate warming in the Arctic, the region is once again "being poisoned from afar," she says.
In years of closely watching the Australian betting markets, I can confidently attest that no other poll moves the betting markets more than Newspoll, further evidence of its disproportionate influence.
There is further evidence of a disproportionate burden.
A risk is said to be ALARP, if the cost of further risk reduction is disproportionate to the benefit.
These results highlight the importance of primary and secondary prevention of diabetes and its complications in both populations and provide further evidence of the disproportionate health burden of registered Indians in Canada.
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CEO of Professional Science Editing for Scientists @ prosciediting.com