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Since most, if not all, fluid return from the extravascular space to the vasculature happens via lymphatic drainage [49], if transcapillary leakage is increased, the lymphatic system may become overwhelmed, further contributing to the development of edema and a relative intravascular volume deficit despite no actual loss of fluid outside the body.
Dyslipidemia triggers endothelial dysfunction further contributing to the development of hypertension [8].
Anemia can reduce the capacity of the blood to transport oxygen (O2), further contributing to the development of hypoxia.
Prior to the onset of diabetes, many patients already show metabolic abnormalities, such as dyslipidemia, further contributing to the development of complications[ 8].
In other words, according to our findings, reduced TIMP-3 expression seems to be related to cell cycle deregulation and tumor cell proliferation, further contributing to the development of an aggressive tumor phenotype.
Additionally, it may affect the chaperone function of α-crystallin, thereby further contributing to the development of cataracts.> -wrap-foot> Autosomalomal dominant; AR, Autosomal recessive; N/A, not available.
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Moreover, supervisory control synthesis can be integrated in this setting, which can further contribute to the development of control systems.
Additionally, lymphatic dilatation, stasis and leakage, and inflammatory reaction secondary to elevated systemic venous pressure, further contribute to the development of PLE [19, 80, 81].
Local selective processes can further contribute to the development of pre- or post-zygotic barriers to reproduction.
Key informant interviews will further contribute to the development of the topic guide for the UMPIRE participant interviews.
Health services researchers could further contribute to the development of mixed methods research in the contexts of instrument development, survey and fieldwork, and non-randomised evaluations.
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