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Each class also contains isoforms that exhibit different binding affinities for IgG subclasses, and further complexities arise from their differential expression on host cell populations and the presence of variant alleles in the low-affinity II and III receptor subtypes [ 12].
While the choice between relative and absolute inequality is already value laden, further complexities arise when, as is often the case, health variables have both a lower and upper bound, and thus can be expressed in terms of either attainments or shortfalls, such as for mortality/survival.
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Further complexity arises from differences in clinical practice and, i.e., the course of oxygen support.
Further complexity arises from the fact that the transcription and expression patterns of PfRH ligands vary between different parasite lines [8], [24].
Notably, further complexity arose with the identification of RAS effectors (e.g. RASSF1-2 or NORE1) with putative tumor suppressor, rather than oncogenic functions [18].
A further complexity arises from the longitudinal nature of the data, which needs to be taken into account when imputing.
Further complexity arises from the fact that effector Th cells may secrete combinations of cytokines and exhibit functional plasticity.
Further complexity arises from the great heterogeneity of molecular lesions found in human tumors [ 4], which is only now becoming fully appreciated.
Further complexity arises from splicing and posttranslational modification of some components (e.g. see Dudognon et al. 2004; Salama et al. 1997; Stankewich et al. 2006).
Further complexity arises because not only do particular individuals carry different combinations of risk alleles, but the genotyping chips do not carry every susceptibility allele for a given locus.
Further complexity arises because one TSS transcript from each gene can undergo alternative splicing within the ORF (hence a single TSS can give rise to multiple transcript variants: Additional file 1: Figure S4).
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CEO of Professional Science Editing for Scientists @ prosciediting.com