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Further clinical phase III studies are required to prove the clinical benefit of nebulized amikacin.
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In a subsequent first-in-human study in three healthy volunteers, the radiation safety was confirmed which supports the translation of this promising radioligand into further clinical phases.
JX-594 treatment in HBV-associated HCC warrants further clinical testing; a Phase II trial is underway.
Based on the results of these earlier efficacy and safety studies, a dose of 50 μg OD was selected for further clinical evaluation in Phase III trials.
Further clinical data from Phase III trials will add to our growing knowledge of MetAP2 inhibitor potential for anti-obesity therapy.
Research in medical education has shown however that students display poor capacity for self-assessment [ 44, 45], and the transition into the clinical phase further reinforces students' feelings of inadequacy [ 46].
Participants were followed through postal questionnaires at approximately 2.5-year intervals (phases 4 8), and further clinical examinations (including an OGTT) were performed in 1997 1999 (phase 5: n = 5,444/2,358) and 2003 2004 (phase 7: n = 4,894/2,074,894/2.
Participants were followed through postal questionnaires at 2.5-year intervals (phases 4 8) and further clinical examinations (including an oral glucose tolerance test) in 1997 1999 (phase 5) and 2003 2004 (phase 7) (12).
Although there were no significant differences among four hospitals in normal bandwidth and phase SD, further clinical validation might be required to determine whether to harmonize the acquisition methodologies and gamma cameras in multicenter study or not.
However, only one study has progressed beyond the phase I or II stage, as further clinical developments are challenging.
These results provide a rationale for further clinical investigations, encouraging the planning of phase II trials with a combined sorafenib-everolimus schedule in MPM patients.
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