This compound is currently undergoing further clinical evaluation.
Further clinical evaluation to define safety and efficacy in larger populations of patients is needed.
This pre-clinical proof-of-concept study warrants further clinical evaluation.
Further clinical evaluation is desired to quantify efficacy in higher risk individuals and in long-term settings.
Phenformin treatment significantly diminished PDAC tumor progression and prolonged tumor doubling time, which provides rationale for further clinical evaluation of phenformin as a therapeutic agent in pancreatic cancer.
A member of this library was found to be a potent and selective β-tryptase inhibitor with a suitable pharmacokinetic profile for further clinical evaluation.
A patient who does poorly on the peak flow measure, or who scores five or more on the questionnaire, will receive further clinical evaluation, including a test known as spirometry, which may lead to a formal diagnosis.
As the stability of DN-2 genome will need to be evaluated in whatever cell line that is selected to produce this virus for further clinical evaluation, we explored the phenotype of DN-2 that has been expanded fewer than three passages in Vero cells.
Drastic inhibition of tumor growth produced by uttroside B in NOD-SCID mice bearing human liver cancer xenografts demonstrates the chemotherapeutic efficacy of uttroside B. These results warrant further clinical evaluation of uttroside B, so that it can be used as an effective chemotherapeutic against liver cancer, which currently has minimal therapeutic options.
In conclusion, our results provide a rationale for further clinical evaluation of darolutamide in enzalutamide-resistant CRPC, in particular in combination with circulating tumor DNA assays that detect AR mutants sensitive to darolutamide, in a precision oncology setting.
These results warrant further clinical evaluation of these two vaccine candidates to assess the added value of a particulate versus soluble form of CSV, in terms of both immunogenicity and protective efficacy.
