The product molecule may bind directly at the active site, blocking further binding of the substrate molecule, or it can bind at the proximity of the active site and influence structural constraints for substrate binding.
The Sp proteins are a family of transcription factors with three zinc-fingers that bind GC-boxes and assist the further binding of the multiprotein complex TFIID promoting the initiation of gene transcription [ 1- 4].
In many cases a protein may bind cooperatively, and it may be affected by further binding proteins.
The Specificity protein-1 (Sp1) is a ubiquitously expressed transcription factor that binds the GC-box [ 19] and assists the further binding of TFIID for the initiation of transcription.
Further binding sites of the selected oligonucleotides are required not to cluster anywhere else.
Radiant light plays across these images, further binding the elements together.
Immobilized redox center (ferrocene) cored PAMAM dendrimers served as a layer for the further binding of biological components.
Further binding assays using a panel of reference glycosphingolipids showed a specific interaction between the F6 fimbriae and a number of neolacto core chain (Galβ4GlcNAc) glycosphingolipids.
We will meet our five per cent emissions reduction target but this government has made no commitments to go further than that and we certainly want to get emissions down as far as we reasonably can but we are certainly in no way looking to make further binding commitments in the absence of very serious like-binding commitments in other countries and there's no evidence of that.
The performance of the genomagnetic assay was firstly demonstrated for a DNA synthetic target by its double-hybridization with both a digoxigenin probe and a biotinylated capture probe, and further binding to streptavidin-modified magnetic beads.
By further binding the secondary antibody, horseradish peroxidase-labeled anti-human IgG, in the presence of the soluble mediator and the enzyme substrate, a current that increased with the analyte concentration was measured.
