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Therefore, we would propose that, as well as inhibiting E2F-1 activity (blocking the inhibition of wnt signalling and hence potentiating β-catenin signalling), Rb may further be required to promote the anti-apoptotic function of BAG-1 because of the ensuing deregulated c-MYC activity in colorectal tumour cells.
(iii) The PPGs should be soluble in the targeted media; they may further be required to pass through biological barriers such as cell membranes and show affinity to specific target components, for example, binding sites on cancer cells or the active site of an enzyme.
Similar(58)
"There'll be a review after this incident to see if anything further is required," Dutton said.
No further proceedings will be required.
Further Steps May Be Required.
Further investigation will be required.
Further evaluation may be required.
Further analyses will be required.
Further empirical evidence may be required.
/ No further exercise is required.
No further action is required".
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