After further adjusting for each of the CSF and MRI biomarkers, the magnitude of correlation of AMNART with cognitive measures was similar irrespective of the biomarker adjusted for.
Model 2 built on this by further adjusting for duration of diabetes, HbA1c, HDL, triglycerides, systolic blood pressure, use of antihypertensive medication, depression, alcohol use, presence of neuropathy, and visual acuity.
These relationships also were unchanged after further adjusting for presence of APOE ε4 and Met-BDNF (Model 6).
However, this significant association disappeared after further adjusting for use of individual micronutrient supplements (P for trend = 0.64).
In additional analyses, after further adjusting for duration of diabetes, hemoglobin A1c, systolic blood pressure, and antihypertensive medications, the results were qualitatively similar (data not shown).
We performed sensitivity analyses, further adjusting for use of hormone replacement therapy (HRT) in regression models in women only and also exploring for birth cohort effects.
In additional analyses, after further adjusting for duration of diabetes, and hemoglobin A1c, the results were qualitatively similar (Supplementary Table 1).
These relationships persisted after further adjusting for coexistence of multiple chronic conditions and persisted in participants who were overweight (BMI: 25.0-< 30.0 kg/m) when stratified analyses were conducted by BMI status.
After further adjusting for number of other diagnoses, the OR associated with homeopathy use among persons with CFS-like illness was attenuated and no longer statistically significant (OR = 2.55, CI = 0.96, 6.71).
Possible confounding by diabetes family history was addressed by further adjusting for history of diabetes in a first-degree relative (information not available in the Spanish centres, Oxford [UK] or Heidelberg [Germany]).
