As to the translation of Spns2-targeting therapy into clinical application, there are still some questions to be further addressed: How is the expression and what is the function of Spns2 in other host cells?
To further address how ß-catenin signaling in the mesenchyme regulates Fgfr2 expression, we silenced β-catenin and Pitx2 expression using siRNA in primary cultures of WT mesenchyme and monitored using real time PCR the levels of Fgfr2 expression.
Given the critical role of c-FLIP downregulation in mediating enhancement of TRAIL-induced apoptosis by LBH589 as demonstrated above, we further addressed how LBH589 decreased c-FLIP levels.
In this study, we further addressed how TF networks coordinate the signal flow and gene expression during the ER stress response and cellulase synthesis.
To further address how FOB1 deletion rescues replication of the rDNA locus, we measured replication using BrdU labeling followed by ChIP/qPCR 25.
In order to understand the implications of the symptom iceberg, we must further address how people interpret and respond to bodily sensations such as symptoms.
To further address how myristylation can influence the dynamics of the C-subunit and how N-myristylation may impact the active site, we performed principal component analysis (PCA) of the MD simulations.
We further address how weighted GLM can be used to depict interactions between E and D on O, and show how to estimate the extent to which getting D mediates an effect that E has on O.
To further address how multiple replication origins evolved over evolutionary time, in this study, we performed a comparative genomic analysis of the H. hispanica replication origins with those obtained from five additional Haloarcula species, specifically focusing on the dissection of the three H. hispanica nonfunctional origins.
To further address how NF-κB contributes to apoptosis, gene profiling by microarray analysis of MEFs was performed, revealing that NF-κB is required for expression of Noxa, a pro-apoptotic BH3-only protein that is induced by genotoxins and that triggers cytochrome c release.
